Vascular ultrasound studies for the non-invasive assessment of vascular flow and patency in experimental surgery in the pig
By Osorio-da Cruz, S.M. - Aggoun, Y. - Cikirikcioglu, M. - Khabiri, E. - Djebaili, K. - Kalangos, A. - Walpoth, B.
| Record number: | 1459043 |
|---|---|
| Category: | human physiology - cardiovascular system - blood flow - animal models - swine - ultrasonography - validity - accuracy - reliability - repeatability - animal welfare - animal use refinement - tissue transplantation - carotid arteries - image analysis - physiological response |
Vascular ultrasound is a reliable non-invasive tool used for the routine assessment of vascular flow and patency in human recipients. We describe the use at three different time points (immediately, 1 week and 4 weeks postsurgery) of ultrasound studies and its validation by angiographic studies in 37 swine undergoing carotid graft replacement. We calculated predictive values (>92%), sensitivity (>85%) and specificity (>92%) with high results at all time points. Ultrasound appeared as an accessible non-invasive technique, providing rapid, safe, repeatable and reliable results. It is an excellent alternative to angiography, avoiding risks inherent to invasive methods and therefore contributing to animal welfare.
Issued: Oct. 2009
Journal Title: Laboratory animals
ISSN: 0023-6772
Volume issue: 43 v. 4 no.
Pages: 333 - 337
AGRICOLA identifier: IND44298008
DOI identifier: 10.1258/la.2009.0080030
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