A new in vitro model for predicting the toxicity of cosmetic products
By Carrara, M. - Cima, L. - Cerini, R. - Carbonare, M.D.
| Record number: | 1665385 |
|---|---|
| Category: | animal use alternatives - cytotoxicity - cosmetics |
A method has been developed whereby cosmetic products which are not soluble in water or in alcohol can be brought into contact with cell cultures by being placed in a cell culture insert, which is then placed in the cell culture well. Preliminary experiments were carried out with L929 cells, and cytotoxicity was evaluated by measuring neutral red uptake and the total protein content of treated cultured cells. Encouraging results were obtained in comparisons of three cosmetic emulsions and of one emulsion containing a range of concentrations of two preservatives, Kathon CG and Bronopol.
Issued: Jan 1992
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 20 v. 1 no.
Pages: 138 - 143
Notes:
Paper presented at the sixth meeting of the Italian in Vitro Cytotoxicity Group, June 20-21, 1991, Padova, Italy.
AGRICOLA identifier: IND20355725
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