The opacifying effects of carteolol HCl and benzalkonium chloride on porcine isolated corneas
By Igarashi, H. - Katsuta, Y. - Nakazato, Y. - Kawasaki, T.
| Record number: | 1665395 |
|---|---|
| Category: | animal use alternatives - cornea |
Porcine isolated corneas (intact, with the epithelium or endothelium plus Descemet's membrane or both epithelium and endothelium plus Descemet's membrane removed) have been incubated with solutions of carteolol HCI (5 X 10(-4) M-5(-4) X 10(-2) M), or solutions of benzalkonium chloride (0.005%-0.05%), or solutions of carteolol (5 X 10(-4) M-5 X 10(-2) M) plus benzalkonium chloride (0.005%). Concentration-dependent opacities developed in corneas with both compounds, but whereas the effect of carteolol seems to involve mainly the endothelium, the effect of benzalkonium seems to involve mainly the epithelium. Possible modes of action of the two compounds are discussed.
Issued: July 1991
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 19 v. 3 no.
Pages: 344 - 351
AGRICOLA identifier: IND20355735
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