Uptake of organic chemicals across fish gills: alternatives to the use of fish populations
| Record number: | 2928435 |
|---|---|
| Category: | Oncorhynchus mykiss - gills - animal welfare - animal use alternatives - polychlorinated biphenyls - polycyclic hydrocarbons - chlorinated hydrocarbons |
In this study, the isolated perfused gills of rainbow trout (Oncorhynchus mykiss) provided a tool for fundamental research on the rate-limiting step in the uptake of organic hydrophobic chemicals. Data obtained using the isolated gills were comparable to those determined in vivo. Whereas several tens of fish need to be used to obtain statistically sound information on uptake rates in vivo, the isolated perfused gills method requires only three or four fish. A significant reduction in animal use is thus obtained.
Issued: Oct 1993
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 21 v. 4 no.
Pages: 453 - 456
AGRICOLA identifier: IND22002720
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