A comparison between COMPACT and Hazard expert evaluations for 80 chemicals tested by the NTP/NCI rodent bioassays
By Brown, S.J. - Raja, A.A. - Lewis, D.F.V.
| Record number: | 2928454 |
|---|---|
| Category: | computer software - prediction - carcinogenesis - structure-activity relationships - organic compounds - carcinogens - animal use alternatives - accuracy |
A total of 80 structurally diverse chemicals for which rodent carcinogenicity data are known, have been evaluated by two predictive computer-based systems, COMPACT and Hazardexpert. The results demonstrate that these two predictive test procedures are, to some extent, complementary, in that COMPACT can identify carcinogens which require metabolic activation, whereas Hazardexpert is able to provide an alert for potentially direct-acting agents. In this study, COMPACT was able to identify correctly most rodent carcinogens, and the Hazardexpert system showed a high concordance with non-carcinogens, in particular. It is suggested that some form of combined approach to the use of predictive methods in chemical safety evaluation may represent a way forward for the future.
Issued: /Dec 1994
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 22 v. 6 no.
Pages: 482 - 500
AGRICOLA identifier: IND22043732
Thanks for your feedback! Please note that we cannot reply to you unless you send us an email.
What are you looking for?
We value your feedback so we can improve the information on the page. Please add your email address if you would like a reply. Thank you in advance for your help.!
Please contact us by email if you have any questions.