Validation of the rat limb bud micromass test in the international ECVAM validation study on three in vitro embryotoxicity tests
By Spielmann, H. - Genschow, E. - Brown, N.A. - Piersma, A.H. - Verhoef, A. - Spanjersberg, M.Q.I. - Huuskonen, H. - Paillard, F. - Seiler, A.
| Record number: | 2928563 |
|---|---|
| Category: | toxicity testing - international cooperation - animal use alternatives - endpoints - cytotoxicity - cell differentiation |
A detailed report is presented on the performance of the rat limb bud micromass (MM) test in a European Centre for the Evaluation of Alternative Methods (ECVAM)-sponsored formal validation study on three in vitro tests for embryotoxicity. Twenty coded test chemicals, classified as non-embryotoxic, weakly embryotoxic or strongly embryotoxic on the basis of their in vivo effects on animals and/or humans, were tested in four laboratories. The outcome showed that the MM test is an experimentally validated test, which holds promise for use for identifying strongly embryotoxic chemicals, but which needs to be improved before it can be recommended for use for regulatory purposes.
Issued: Sept. 2004
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 32 v. 3 no.
Pages: 245 - 274
AGRICOLA identifier: IND43662294
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