Chimeric Newcastle disease virus-vectored vaccine protects chickens against H9N2 avian influenza virus in the presence of pre-existing NDV immunity
By Jingjing Liu - Ling Xue - Shunlin Hu - Hao Cheng - Yonghuan Deng - Zenglei Hu - Xiaoquan Wang - Xiufan Liu
| Record number: | 6206903 |
|---|---|
| Category: | chickens - Newcastle disease - hemagglutination - Orthorubulavirus - enzymes - antibodies - Influenza A virus - flocks - Avian orthoavulavirus 1 - hemagglutinins - viruses - recombinant vaccines - animal use reduction |
A chimeric Newcastle disease virus (NDV) vector (NDV/AI4-TFHN) was constructed with the replacement of the ectodomains of the fusion and hemagglutinin-neuraminidase proteins by those from avian paramyxovirus type 2. The chimeric virus induced high antibody response in chickens pre-immunized with NDV. A recombinant vaccine candidate, NDV/AI4-TFHN-H9, expressing the hemagglutinin of H9N2 avian influenza virus, was generated, on the basis of the chimeric NDV vector mentioned above. The NDV/AI4-TFHN-H9 vaccine elicited H9-specific hemagglutination inhibition antibodies in chickens pre-immunized with NDV vaccine, and reduced the numbers of chickens shedding virus after H9N2 challenge. NDV/AI4-TFHN-H9 could serve as an alternative vaccine for the prevention of H9N2 infection in commercial poultry flocks.
Issued: 2018
Journal Title: Archives of virology
ISSN: 0304-8608
Volume issue: 163
Pages: 3365 - 3371
Publisher: Springer Vienna
AGRICOLA identifier: IND606206903
DOI identifier: 10.1007/s00705-018-4016-2
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