Cytotoxic and genotoxic effects of 10 N-nitroso compounds in a human hepatoma cell line (Hep G2): comparison with human hepatocyte primary cultures
By Campart, G.B. - Canonero, R. - Mereto, E. - Ferro, M.
| Record number: | 1577942 |
|---|---|
| Category: | animal use alternatives - nitroso compounds - cytotoxicity - toxicity - cell lines - hepatocytes - neoplasms - genotoxicity |
A comparison of data from assays performed in cells of an established line derived from a human hepatoblastoma (Hep G2) with those previously obtained in freshly-isolated human hepatocytes, reveals that the latter are, by varying degrees, more sensitive than the former to the cytotoxic and genotoxic effects of 10 N-nitroso compounds, independently of their nature as proximate or ultimate carcinogens.
Issued: Sept 1989
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 17 v. 1 no.
Pages: 22 - 27
AGRICOLA identifier: IND91027867
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