Toxicity of ethylene-bis-dithiocarbamates (EBDCs) in a human neuroblastoma cell line
By Cova, D. - Fumagalli, P. - Santagostino, A.
| Record number: | 1655267 |
|---|---|
| Category: | animal use alternatives - cell lines - cytotoxicity |
The aim of our research was the in vitro evaluation of the neurotoxic effects of three EBDCs (Nabam, Zineb and Maneb) and ETU on SK-N-BE human neuroblastoma cells as a model for neurotoxicity in humans. The EC50 value was used as an index of the toxicities of these compounds. Since Zineb and Maneb contain zinc and manganese as cations, respectively, in order to determine the contributions of these metals, the EC50s of zinc chloride and manganese chloride were also evaluated. Nabam, Zineb and Maneb had EC50 values ranging from 1 micromolar to 30 micromolar; the EC50s of manganese and zinc in this human cell line were found to be of the same order of magnitude as those of the EBDC fungicides. These in vitro effects are discussed in relation to the possible use of neuronal cell lines for detecting the neurotoxicities of these compounds.
Issued: Feb 1991
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 19 v. 1 no.
Pages: 39 - 40
Notes:
Paper presented at the fifth meeting of the Italian Group for the Application of Tissue Cultures in Toxiciology, May 31-June 1, 1990, Milan, Italy.
AGRICOLA identifier: IND20337487
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