Computerised image analysis of nuclear enlargement assay in HeLa cells
By Rizzi, R. - Re, F. - Chiesara, E.
| Record number: | 1655286 |
|---|---|
| Category: | animal use alternatives - carcinogens - computer analysis |
It has been observed that cells often respond to carcinogens by nuclear enlargement. For this reason, new morphometric approaches have been developed to evaluate cell modifications in pre-carcinogenesis assays. Morphometric computerised automatic analysis, with original software, was performed on HeLa cells treated with various compounds (hydroxyurea, dimethylnitrosamine, N-methyl-N'-nitro-nitrosoguanidine and cyclophosphamide) to evaluate nuclear size changes.
Issued: Feb 1991
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 19 v. 1 no.
Pages: 41 - 47
Notes:
Paper presented at the fifth meeting of the Italian Group for the Application of Tissue Cultures in Toxiciology, May 31-June 1, 1990, Milan, Italy.
AGRICOLA identifier: IND20337511
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