Anomalous dose-response relationship due to association colloidal behaviour of soluble amphiphilic compounds
By Isomaa, B. - Hagerstrand, H. - Toivola, D.
| Record number: | 1665084 |
|---|---|
| Category: | animal use alternatives - crystals - micelles |
Water-soluble amphiphiles may, above a certain concentration, form colloidal aggregates (micelles or liquid crystals). If such aggregates are formed, there may be a competition between the micelles or the liquid crystals and the biological target for the monomeric form of the amphiphile. This may reduce the number of monomers available for the biological target, which in turn may be reflected in concentration-dependent processes. Therefore, caution should be taken when examining dose-response with soluble amphiphiles forming micelles at low concentrations.
Issued: Apr 1991
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 19 v. 2 no.
Pages: 194 - 198
Notes:
Paper presented at the "Eighth Congress on In Vitro Toxicology of the Scandinavian Society for Cell Toxicology," Sept. 13-16, 1990, Norway.
AGRICOLA identifier: IND20355151
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