In vitro cytotoxic effects of extracellular ATP
By Murgia, M. - Pizzo, P. - Zanovello, P. - Zambon, A. - Di Virgilio, F.
| Record number: | 1665371 |
|---|---|
| Category: | animal use alternatives - cytotoxicity - adenosine triphosphate |
ATP is released in the body from several cells under various physiological and pathological conditions. A number of authors have postulated a role for extracellular ATP (ATPo) as a neurotransmitter, a secretagogue or an inflammatory mediator. Here, we propose an additional role for ATPo, as a cytotoxic factor, and discuss in vitro experiments showing that this nucleotide causes cell death by two mechanisms: colloido-osmotic lysis and apoptosis.
Issued: Jan 1992
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 20 v. 1 no.
Pages: 66 - 70
Notes:
Paper presented at the sixth meeting of the Italian in Vitro Cytotoxicity Group, June 20-21, 1991, Padova, Italy.
AGRICOLA identifier: IND20355711
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