Correlation between in vitro cytotoxicity and octanol/water partition coefficient of 29 substances from the MEIC programme
By Halle, W. - Baeger, I. - Ekwall, B. - Spielmann, H.
| Record number: | 1665393 |
|---|---|
| Category: | animal use alternatives - cytotoxicity - chemical substances |
Single linear regression analysis was used for chemicals of the MEIC (multicentre evaluation of in vitro cytotoxicity) project, to obtain a correlation between in vitro cytotoxicity determined in various test systems, according to data from the literature, and their lipophilicity. A linear correlation coefficient of 0.76 was determined between the IC50 average values (geometrical mean of two or more IC50 values per substance) of 29 MEIC substances and their octanol/water partition coefficient (owp). Since the MEIC substances were selected from a broad spectrum of structurally unrelated classes of chemicals, it may be possible to make close predictions of the general in vitro cytotoxicities of chemicals from their owp coefficients.
Issued: July 1991
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 19 v. 3 no.
Pages: 338 - 343
AGRICOLA identifier: IND20355733
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