Animal Models of Substance Abuse and Addiction: Implications for Science, Animal Welfare, and Society
By Lynch, Wendy J. - Nicholson, Katherine L. - Dance, Mario E. - Morgan, Richard W. - Foley, Patricia L.
| Record number: | 2271837 |
|---|---|
| Category: | alcohol abuse - drug abuse - pathophysiology - rehabilitation (people) - human health - human diseases - medicine - biomedical research - research methods - animal experimentation - animal models - screening - therapeutics - laboratory animals - animal use refinement - animal welfare - bioethics - Institutional Animal Care and Use Committee |
Substance abuse and addiction are well recognized public health concerns, with 2 NIH institutes (the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism) specifically targeting this societal problem. As such, this is an important area of research for which animal experiments play a critical role. This overview presents the importance of substance abuse and addiction in society; reviews the development and refinement of animal models that address crucial areas of biology, pathophysiology, clinical treatments, and drug screening for abuse liability; and discusses some of the unique veterinary, husbandry, and IACUC challenges associated with these models.
Issued: June 2010
Journal Title: Comparative medicine
ISSN: 1532-0820
Volume issue: 60 v. 3 no.
Pages: 177 - 188
AGRICOLA identifier: IND44410836
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