The Galileo Data Bank on toxicity testing with in vitro alternative methods. II. Toxicology profiles of 20 chemicals

By Loprieno, N. - Boncristiani, G. - Bosco, E. - Nieri, M. - Loprieno, G.

The identification of the hazard of chemicals to man has relied on the use of several animal models. However, the availability of various cell toxicity models as alternatives to the use of animals has stimulated attempts to evaluate in vitro data for use in the prediction of human toxicity. The cell toxicity models developed previously are capable of indicating a variety of endpoints susceptible to the activity of various chemical substances. The in vitro data derived so far from testing a variety of types of chemicals, have been used to develop toxicology profiles for twenty chemicals, which are presented in this paper. Data have been selected from among those already entered in the Galileo Data Bank, a computerised data system containing all the available existing data derived using in vitro methods.