Physiologically-based Pharmacokinetic Modelling for the Reduction of Animal Use in the Discovery of Novel Pharmaceuticals
| Record number: | 295259 |
|---|---|
| Category: | animal use reduction - drugs - laboratory animals - models - pharmacokinetics |
The challenges of physiologically-based pharmacokinetic (PBPK) modelling and approaches to replacing the use of animals, in order to determine drug pharmacokinetics, are discussed. Reference is made to the limitations of in vivo animal studies in drug discovery. In particular, the ways in which animal studies contribute to drug attrition during the post-preclinical phase of testing are considered.
Issued: Dec. 2010
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 38 v. 1 no.
Pages: 81 - 85
Publisher: FRAME
AGRICOLA identifier: IND44585418
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